Irifone Gel 5% 50g  is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.

Indications/Uses: Relief of rheumatic and muscular pain as a 5% gel or 10% cream

When this drug is applied simultaneously with:

  • digoxin slightly increased the concentration of digoxin in plasma.
  • itraconazole greatly increases the concentration of atorvastatin in plasma, apparently due to inhibition of itraconazole its metabolism in the liver that occurs with the participation of isoenzyme CYP3A4; increased risk of myopathy.
  • colestipol may decrease the concentration of atorvastatin in plasma, with lipid-lowering effect is enhanced.
  • antacids containing magnesium hydroxide and aluminum hydroxide, reduce the concentration of atorvastatin by approximately 35%.
  • cyclosporine, fibrates (including gemfibrozil), azole antifungals derivatives, nicotinic acid increases the risk of myopathy.

Side effects include :

Digestive system: nausea, vomiting, steroid ulcer, and duodenal ulcer, esophagitis, bleeding and perforation of the gastrointestinal tract, increased or decreased appetite, hiccups.

Metabolism: the negative nitrogen balance due to protein catabolism, hypocalcemia, weight gain, increased sweating.